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KMID : 0370019870010000118
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Chung-Ang Journal of Pharmacal Sciences
1987 Volume.1 No. 0 p.118 ~ p.128
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Studies on the Water Extract of Several Chinese Drugs on the Allergic Reaction and Serum Protein Fraction
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정진모/Chung, Zin Mo
김창종/Kim, Chang Johng
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Abstract
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The antiallergic activities of water extract of 35 traditional chinese drugs have been assessed from their relative activities in the passive cutaneous anaphylaxis(PCA) reaction in the MCSAb-sensitized rats. It was found that seven chinese drugs, Cocculi Trilobi Lignum, Coptidis Rhizoma, Phellodendri Cortex, Eleutherococci Cortex, Glycyrrhizae Radix, Achyranthis Radix, Eucommiae Cortex were more active than others in the PCA test. Especially, above seven chines drugs inhibited the acute allergic reaction such as passive cutaneous anaphylaxis by mast cell sensitizing antibody and histamine-induced anaphylaxis, and the delayed allergic reaction such as the Freund´s complete adjuvant arthritis and DNCB-induced dermatitis. Their activities ascertained that the chinese drugs decrease the capillary permeability and the serum r-globulin level.
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